The Cancer Degradome pdf epub mobi txt 電子書下載2025

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出版者:

作者:Edwards, Dylan (EDT)/ Hoyer-hansen, Gunilla (EDT)/ Blasi, Francesco (EDT)/ Sloane, Bonnie F. (EDT)

出品人:

頁數:984

译者:

出版時間:2008-10

價格:$ 292.67

裝幀:

isbn號碼:9780387690568

叢書系列:

圖書標籤:

癌癥
蛋白質降解
腫瘤微環境
藥物靶點
蛋白質組學
癌癥治療
信號通路
PROTAC
分子生物學
生物化學

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具體描述

This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that have emerged between proteolysis and cell signalling; how the degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to targeting proteolysis for therapy.