This book describes the use of smoothing techniques in statistics and includes both density estimation and nonparametric regression. Incorporating recent advances, it describes a variety of ways to apply these methods to practical problems. Although the emphasis is on using smoothing techniques to explore data graphically, the discussion also covers data analysis with nonparametric curves, as an extension of more standard parametric models. Intended as an introduction, with a focus on applications rather than on detailed theory, the book will be equally valuable for undergraduate and graduate students in statistics and for a wide range of scientists interested in statistical techniques.
The text makes extensive reference to S-Plus, a powerful computing environment for exploring data, and provides many S-Plus functions and example scripts. This material, however, is independent of the main body of text and may be skipped by readers not interested in S-Plus.
Reviewer:
"An up-to-date book with the most recent state of the art. . . . Accessible to nonmathematical readers. . .There is a rich choice of examples, exercises, hints for further reading and S-Plus illustrations." --N. Veraverbeke, Limburgs Universitair Centrum, Diepenbeek, Belgium "[T]his book provides an overview of smoothing techniques used in data analysis, with emphasis on one- and two-dimensional data. The authors' aim is to complement the existing books by focusing on intuitive presentation of the ideas and on practical issues of inference rather than estimation. The book consists of eight chapters and 193 pages, with the first two chapters devoted to density estimation and the last six . . . concentrating on smoothing in regression and time series. Real data are used throughout to illustrate the techniques. . . . [T]he book attempts to be both a practical introduction to smoothing and an outline of the methodological and theoretical development of the subject. It does reasonably well at both, but its strength is in showing the techniques and illustrating them on datasets. I think it will be a quite useful book for a research or applied statistician wanting an overview of the subject with examples and references."--Technometrics "This instructive textbook provides an excellent introduction to smoothing, with an emphasis on methods, applications on real data, and subsequent inferences. If you are an applied and/or a quantitatively oriented researcher who is unfamiliar with (or suspicious of) smoothing methods, you will definitely appreciate the book's level and practical focus, as the authors have presented the methodology and have demonstrated implementation clearly on real datasets with descriptive interpretations of the results. . . . This book would serve as an excellent textbook for a masters-level course on smoothing because it focuses on actual practice, through real datasets and corresponding software (available on-line as described in Appendix A) and because of the instructive exercises that conclude each chapter."--Journal of the American Statistical Association
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这本书的封面设计真是让人眼前一亮,那种深邃的蓝色调配上简洁的白色字体,透露出一种专业而又不失沉稳的气质。我原本以为这会是一本枯燥的教科书,但翻开之后才发现,作者在行文的流畅度和逻辑构建上花了不少心思。它不像某些医学著作那样堆砌术语,而是用一种近乎讲故事的方式,娓娓道来高脂血症的复杂机制。特别是关于脂蛋白代谢的章节,作者通过一系列生动的比喻,将那些晦涩难懂的生化过程描绘得清晰易懂,即便是初次接触这个领域的读者,也能迅速抓住核心脉络。我尤其欣赏它对现有治疗指南的梳理,那种条分缕析的对比,让人能清晰地看到不同国家和地区指南之间的细微差别,这对于临床决策的制定无疑具有极高的参考价值。读完前几章,我已经感觉到自己的知识体系得到了极大的拓宽,不再是零散的记忆点,而是一个结构完整、逻辑严密的知识网络正在搭建起来。
评分最让我感到惊喜的是,这本书在讨论药物选择时,摆脱了绝对化的倾向,非常客观地呈现了不同药物的长期风险与收益的权衡。它没有盲目推崇某一种“明星药物”,而是将每一种干预手段置于一个更广阔的临床情境中去评估。例如,它详细对比了贝特类药物在合并高甘油三酯血症患者中的应用差异,并结合了最新的心血管事件获益研究结果,给出了非常中肯的建议。这种平衡的视角,避免了读者陷入非黑即白的误区。而且,书中对患者管理中的非药物干预,如饮食结构调整和运动方案的科学性也进行了深入探讨,而不是简单地草草带过。这体现了作者对高脂血症管理是一个系统工程的深刻理解,绝非单靠几颗药丸就能解决的问题。
评分这本书的排版和图表制作水平堪称一流,这对于理解复杂的数据模型至关重要。许多药物在体内的药代动力学曲线、不同降脂药物对动脉粥样硬化斑块稳定性的影响对比图,都绘制得清晰、美观且信息量巨大。我尤其喜欢它在讨论药物相互作用和副作用管理时所采用的矩阵图表,将常见药物的潜在风险一目了然地呈现出来,这比单纯的文字描述要直观得多,能大大减少临床应用中的疏忽。整个阅读体验非常顺畅,纸张的质感和印刷的清晰度也符合一本高品质专业书籍的标准。总的来说,这本书不仅是知识的载体,更是一种高效率的工具,它把复杂的临床决策过程,通过精良的视觉呈现,变得更加触手可及和易于掌握。
评分这本书的深度绝对超出了我的预期,我原本只是想找本工具书来快速查阅最新的药物剂量和适应症,没想到它竟然深入探讨了药物研发背后的基础科学原理。作者对新型降脂药物,比如PCSK9抑制剂和siRNA疗法的作用靶点、作用机制进行了极其细致的剖析,甚至提到了很多尚未完全成熟的前沿研究方向。我记得有一段专门分析了基因多态性对他汀类药物反应差异的影响,引用了大量原始文献的数据,那种严谨到近乎苛刻的学术态度,让我对这本书的权威性深信不疑。对于那些希望从“应用”层面深入到“机制”层面的临床医生或研究人员来说,这本书简直是宝藏。它不仅告诉你“怎么做”,更重要的是解释了“为什么能这么做”,这种知其然更知其所以然的感觉,是很多快餐式医学读物无法提供的。
评分我阅读这本书时,最大的感受就是它的实用性和时效性。它不是那种陈旧的参考书,而是紧密贴合了近几年全球心血管疾病预防指南的更新。作者在回顾历史数据和经典研究的同时,从未停止过对最新临床试验结果的整合。我特别关注了关于二级预防中胆固醇目标值设定的部分,书中清晰地梳理了从过去的绝对数值目标到目前更侧重于风险分层和LDL-C降低幅度的转变逻辑。对于我日常工作中需要处理的复杂病例,这本书提供了一套非常清晰的决策树框架,帮助我快速确定下一步的治疗路径。那些穿插在正文中的“临床要点速览”小框,简直是救急神器,在查阅特定信息时效率极高,充分考虑了专业人士紧张的工作节奏。
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