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Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life.

JENNIFER A. DOUDNA, Ph.D. is a professor in the Chemistry and the Molecular and Cell Biology Departments at the University of California, Berkeley, investigator with the Howard Hughes Medical Institute, and researcher in the Molecular Biophysics and Integrated Bioimaging Division at the Lawrence Berkeley National Laboratory. She is internationally recognized as a leading expert on RNA-protein biochemistry, CRISPR biology, and genome engineering. She lives in the Bay Area.SAMUEL H. STERNBERG, Ph.D., is a biochemist and author of numerous high profile scientific publications on CRISPR technology. He is starting his own laboratory at Columbia University, as assistant professor in the Department of Biochemistry and Molecular Biophysics, beginning in 2018. He lives in New York City.

SAMUEL H. STERNBERG, Ph.D., is a biochemist and author of numerous high profile scientific publications on CRISPR technology. He is starting his own laboratory at Columbia University, as assistant professor in the Department of Biochemistry and Molecular Biophysics, beginning in 2018. He lives in New York City.

Prologue: The Wave
Part I The Tool
1 The Quest for a Cure
2 A New Defense
3 Cracking the Code
4 Command and Control
Part II The Task
5 The CRISPR Menagerie
6 To Heal the Sick
7 The Reckoning
8 What Lies Ahead
Epilogue: The Beginning
Acknowledgments
Notes
Index
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