The Emperor of All Maladies pdf epub mobi txt 電子書 下載2025
Siddhartha Mukherjee is a cancer physician and researcher. He is an assistant professor of medicine at Columbia University and a staff cancer physician at the CU/NYU Presbytarian Hospital. A former Rhodes scholar, he graduated from Stanford University, University of Oxford (where he received a PhD studying cancer-causing viruses) and from Harvard Medical School. His laboratory focuses on discovering new cancer drugs using innovative biological methods. Mukherjee trained in cancer medicine at the Dana Farber Cancer Institute of Harvard Medical School and was on the staff at the Massachusetts General Hospital. He has published articles and commentary in such journals as Nature, New England Journal of Medicine, Neuron and the Journal of Clinical Investigation and in publications such as the New York Times and the New Republic. His work was nominated for Best American Science Writing, 2000 (edited by James Gleick). He lives in Boston and New York with his wife, Sarah Sze, an artist, and with his daughter, Leela.
- 科普
- 癌癥
- 醫學
- 普利策奬
- 科學
- 生命
- cancer
- science
Starred Review. Mukherjee's debut book is a sweeping epic of obsession, brilliant researchers, dramatic new treatments, euphoric success and tragic failure, and the relentless battle by scientists and patients alike against an equally relentless, wily, and elusive enemy. From the first chemotherapy developed from textile dyes to the possibilities emerging from our understanding of cancer cells, Mukherjee shapes a massive amount of history into a coherent story with a roller-coaster trajectory: the discovery of a new treatment--surgery, radiation, chemotherapy--followed by the notion that if a little is good, more must be better, ending in disfiguring radical mastectomy and multidrug chemo so toxic the treatment ended up being almost worse than the disease. The first part of the book is driven by the obsession of Sidney Farber and philanthropist Mary Lasker to find a unitary cure for all cancers. (Farber developed the first successful chemotherapy for childhood leukemia.) The last and most exciting part is driven by the race of brilliant, maverick scientists to understand how cells become cancerous. Each new discovery was small, but as Mukherjee, a Columbia professor of medicine, writes, "Incremental advances can add up to transformative changes." Mukherjee's formidable intelligence and compassion produce a stunning account of the effort to disrobe the "emperor of maladies." (Nov.) (c)
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具體描述
讀後感
起初，一个淋巴细胞发现它无法摆脱这个念头：为什么我拥有全套的DNA，却无法自由地有丝分裂呢？ 它苦苦地回溯自己的基因记忆。在它最古老的祖母身上，分明保留了一种和现在完全不一样的模糊光景：胚胎、分裂、增殖、自由、生命…… 但为什么它这个只有短短几周生命的淋巴细胞会...
評分“……可以认为癌症在试图仿效一个再生器官；或者更令人不安的是在仿效一个再生的有机体。其对永生不死的追求反映了我们自己的追求，埋藏在我们的胚胎和器官重生中的一种追求。有一天，如果癌症成功了，它将产生一个比其宿主更加完美的生命，具有不死的特性和增殖的动力。...
評分医学就是医学，没什么中外东西。像癌症这种病，发现它对抗它的必定是一个充满活力充满基础发明创造和认识能力的社会。不单是医学的发展，包括化学、生物学甚至物理学等等各种学科的交融才能从多个角度对这种可怕的病症展开作战，从手术到放疗到化疗到基因攻击，挽救了无数人的...
評分整个阅读过程中我的感情十分复杂，时常会回想起当初在医院照顾爸爸的日子。 这本书写得很通俗很易懂，梳理了人类对抗癌症的历史。在我看来有几个面，从癌症角度，从科研角度，从病人角度，从医生角度，无论从哪个角度来看都有很深的感触。 有时候，不是我们没有努力，而是对手...
評分医学就是医学，没什么中外东西。像癌症这种病，发现它对抗它的必定是一个充满活力充满基础发明创造和认识能力的社会。不单是医学的发展，包括化学、生物学甚至物理学等等各种学科的交融才能从多个角度对这种可怕的病症展开作战，从手术到放疗到化疗到基因攻击，挽救了无数人的...
用戶評價
除瞭用科普的筆觸去寫人類對癌癥認知的曆史，作者還調查瞭“和癌癥做鬥爭”的政治和社會運作。幾乎是想象中科普作者的最佳語氣。就像之前讀過這本書的一位朋友說的，在我們這個時代大概每個人都會有機會旁觀或親曆對抗癌癥的戰鬥。
评分除瞭用科普的筆觸去寫人類對癌癥認知的曆史，作者還調查瞭“和癌癥做鬥爭”的政治和社會運作。幾乎是想象中科普作者的最佳語氣。就像之前讀過這本書的一位朋友說的，在我們這個時代大概每個人都會有機會旁觀或親曆對抗癌癥的戰鬥。
评分Fantastic account of the struggle against a diabolical enemy borne out of our own body..
评分都說文學就是人學，讀完此書意識到醫學也是人學。Mukherjee似乎特彆擅長抓住科學研究發展與時代背景之間的關係，而刻畫一個個人物時又入骨般有力。讀到War on Cancer摺射齣的堅定的信念與空虛的狂熱，讀到禁煙運動與煙草公司斡鏇的艱難麯摺，讀到在理解癌癥的基因基礎之路上的抽絲剝繭，總忍不住眼紅鼻酸。然而同樣讓我印象深刻的是書中一個個的人，從Larger than life的化療之父Farber到無數被癌癥改變瞭人生的病人。疾病可以成為隱喻，正是在於疾病作為一個獨特的透鏡反射齣的人性。
评分除瞭用科普的筆觸去寫人類對癌癥認知的曆史，作者還調查瞭“和癌癥做鬥爭”的政治和社會運作。幾乎是想象中科普作者的最佳語氣。就像之前讀過這本書的一位朋友說的，在我們這個時代大概每個人都會有機會旁觀或親曆對抗癌癥的戰鬥。
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