Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
这本书主要围绕Jennifer Doudna, 回顾了CRISPR和基因编辑的探讨. 写的跌宕起伏, 描述了科学研究者之间秘密竞争同时又对自然保护好奇心展开合作. 不同的研究者展示了非常不一样的个性. 后面几章讨论bioethics 和人类基因改造, 我不大喜欢. 作者自己个人想法太多,觉得有点肤浅, ...
評分想找本一两年内的最新科普书来刷新一下自己,但没找到合适的。倒是看到这本传记口碑不错,觉得书里写的既然是生物科技前沿人物,那多多少少也该有些科普内容吧。 作为人物传记,这本书还是很不错的,没有按年代写流水账,即便是主角Doudna的经历,也是详略得当、重点突出,节奏...
評分1、 根据我目前的认知,大部分生命活动的调控是精细而复杂的,并非敲除或改变一段序列就能产生显著效果。生命系统的复杂性也预示任意改造一段序列可能会有意外后果。此外,脱靶效应也会限制基因编辑技术的人体应用。所以,大规模的基因设计短时期内还只是个愿景,但早早开始考...
評分作者以2020年诺贝尔化学奖得主Jennifer Doudna为主线,讲解了基因编辑技术的发展过程,以及对当下和未来的影响,并将众多研究者饱满地呈现出来。科学知识与人物故事交织在一起,非常精彩的一本书。 作者从19世纪的达尔文和孟德尔,讲到DNA结构被发现,再到人类基因组计划。众多...
should be the code breakers. 一開始是抱著Bill Gates 推薦過所以想看,不得不說有點失望。但是看到Bill and Melinda Gates Foundation 資助瞭以後就也沒那麼意外瞭。
评分很難評價,還是不打分瞭。作者很明顯是高質量傳記作者,他的能力已經在喬布斯傳當中充分展現瞭,在這本書當中更是展露無疑。science部分不難理解,但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者,自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角,去“客觀”地記錄CRISPR的曆史。很多事件的發生過程,作者明明有相當大的篇幅可以詳細地描述,反而實際上閃爍其詞,直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好,諷刺效果max,真是罵人於無形。 who tells the story還挺重要的,Lander在cell上的文章是這個目的,這本書同樣是這個目的。心潮澎湃大可不必,不過的確是一個勵誌故事。
评分很精彩的故事,高尖端的科技,科學傢的爭名奪利,關於道德的爭論,都很有意思,不過感覺作者夾帶私貨略多
评分偵探小說一樣,好看的簡直停不下來,比前一步著作 達芬奇 好看的多,讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現,大傢爭來爭去,DNA結構的發現,大傢爭來爭去,人類基因組計劃,大傢爭來爭去, crisper-cas9,大傢爭來爭去。其實你發現沒有,個人的貢獻是有限的,沒有誰,地球照樣轉。科學的發現和進步,是一個水到渠成,成韆上萬的人一步一步做齣來的,個人的貢獻往往被放大,而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人,也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看,美國也有尖子班,張峰也上補習班的,不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
评分感覺看瞭一部宮鬥劇?
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