The Code Breaker

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Walter Isaacson, a professor of history at Tulane, has been CEO of the Aspen Institute, chair of CNN, and editor of Time. He is the author of Leonardo da Vinci; The Innovators; Steve Jobs; Einstein: His Life and Universe; Benjamin Franklin: An American Life; and Kissinger: A Biography, and the coauthor of The Wise Men: Six Friends and the World They Made. Visit him at Isaacson.Tulane.edu.

出版者:Simon & Schuster
作者:Walter Isaacson
出品人:
页数:560
译者:
出版时间:2021-3-9
价格:USD 29.99
装帧:Hardcover
isbn号码:9781982115852
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The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

具体描述

读后感

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想找本一两年内的最新科普书来刷新一下自己,但没找到合适的。倒是看到这本传记口碑不错,觉得书里写的既然是生物科技前沿人物,那多多少少也该有些科普内容吧。 作为人物传记,这本书还是很不错的,没有按年代写流水账,即便是主角Doudna的经历,也是详略得当、重点突出,节奏...  

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I enjoyed reading the book. I appreciate that Walter has explained the concepts of biochemistry, a subject rather unfamiliar to me, in a both thorough and understandable way, covering a wide range of topics around CRISPR, including the history, the scientif...  

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这本书主要围绕Jennifer Doudna, 回顾了CRISPR和基因编辑的探讨. 写的跌宕起伏, 描述了科学研究者之间秘密竞争同时又对自然保护好奇心展开合作. 不同的研究者展示了非常不一样的个性. 后面几章讨论bioethics 和人类基因改造, 我不大喜欢. 作者自己个人想法太多,觉得有点肤浅, ...  

用户评价

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除了学习科学知识 还借鉴得到成功科学家的品质 追求卓越注重合作然而又能严格管理自己的时间界限 生命科学的魅力 疫情初期紧锣密鼓的研究与疫苗开发 意外还有1984 vs. Brave New World这一对比重现 虽然有主POV CRISPR学术之争的叙述个人感觉尚且公正 希望能多收集一些行家线报实验室风云!

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最多3.5星吧。与其说这是一本传记不如说是科普。然而作者写科普书的能力远不如其他专业学者。 关于基因编辑的道德问题作者花了很长的篇幅讨论,这个话题写几本书都可以,作者在这方面的理论知识显然还不够。道德问题谁都有权利发言,但写太多了看着很乏味。 零星的点:金字塔尖的竞争很激烈,人尖们犯过的错走过的弯路有借鉴意义,国外的前沿科学研究值得时刻跟进和关注。

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最多3.5星吧。与其说这是一本传记不如说是科普。然而作者写科普书的能力远不如其他专业学者。 关于基因编辑的道德问题作者花了很长的篇幅讨论,这个话题写几本书都可以,作者在这方面的理论知识显然还不够。道德问题谁都有权利发言,但写太多了看着很乏味。 零星的点:金字塔尖的竞争很激烈,人尖们犯过的错走过的弯路有借鉴意义,国外的前沿科学研究值得时刻跟进和关注。

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感觉看了一部宫斗剧?

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侦探小说一样,好看的简直停不下来,比前一步著作 达芬奇 好看的多,读达芬奇的时候 一直瞌睡。这本书简直停不下来。微积分的发现,大家争来争去,DNA结构的发现,大家争来争去,人类基因组计划,大家争来争去, crisper-cas9,大家争来争去。其实你发现没有,个人的贡献是有限的,没有谁,地球照样转。科学的发现和进步,是一个水到渠成,成千上万的人一步一步做出来的,个人的贡献往往被放大,而更多的人则被忽略。感觉Jennifer是一个很爱抢功劳的人,也许是中国人都zhangfeng有同情。不过她的合作者都疏远了她。鸡血的中国妈妈可以看看,美国也有尖子班,张峰也上补习班的,不过他上的是将荧光蛋白重组表达的相关工作。最不喜欢书里面的thought experiment, 是这本书最大的败笔

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