This revision of the highly acclaimed Hayes' "Handbook of Pesticide Toxicology" is an in-depth, scientific sourcebook concerning use, properties, effects, and regulation of pesticides. This edition is a comprehensive examination by international experts from academia, government research, and the private sector of critical issues related to the need, use, and nature of chemicals used in modern pest management. This two-volume set contains up-to-date information on a broad range of topics which establishes context of pesticide use and outlines how they are scientifically evaluated. Experts from a variety of disciplines contribute to this work. Some provide a fresh look at existing information, and others look ahead at issues that are central to understanding pesticide use and toxicology in modern integrated pest management. It establishes and describes a context for evaluation of pesticide use in agriculture, residential pest control and public health. It includes important discussion of strategies for pesticide risk assessment. All major classes of pesticide are considered. Different routes of exposure are critically evaluated. Current regulatory issues are defined. Emerging issues concern topics of special relevance in the future. Agents are reviewed by experts from academia, government research, and the private sector.