This book covers the key topics for drug discovery from the perspective of the practising industrial scientist and manager. Presenting all aspects of the subject from initial lead through to final development, this new edition builds on the highly successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and chemoinformatics, alongside revised and updated original chapters. Introducing the cross-disciplinary topics needed, Medicinal Chemistry: Principles and Practice 2nd Edition embraces descriptions of targets, biology, metabolism and pharmacokinetics, genetics, patents and development chemistry. New case histories, strategy and tactics for drug discovery are also introduced. With many chapters written by practitioners from within the pharmaceutical industry, it is an invaluable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.
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