具体描述
So many women who do everything right to stay healthy still wind up with breast cancer, heart disease, or osteoporosis. In The Fragile Wisdom, Grazyna Jasienska provides an evolutionary perspective on the puzzle of why disease prevention among women is so frustratingly difficult. Modern women, she shows, are the unlucky victims of their own bodies’ conflict of interest between reproductive fitness and life-long health.
The crux of the problem is that women’s physiology has evolved to facilitate reproduction, not to reduce disease risk. Any trait—no matter how detrimental to health in the post-reproductive period—is more likely to be preserved in the next generation if it increases the chance of giving birth to offspring who will themselves survive to reproductive age. To take just one example, genes that produce high levels of estrogen are a boon to fertility, even as they raise the risk of breast cancer in mothers and their daughters.
Jasienska argues that a mismatch between modern lifestyles and the Stone Age physiology that evolution has bequeathed to every woman exacerbates health problems. She looks at women’s mechanisms for coping with genetic inheritance and at the impact of environment on health. Warning against the false hope gene therapy inspires, Jasienska makes a compelling case that our only avenue to a healthy life is prevention programs informed by evolutionary understanding and custom-fitted to each woman’s developmental and reproductive history.
作者简介
Grazyna Jasienska is Professor at the Institute of Public Health, Jagiellonian University Medical College, Krakow, Poland.
目录信息
1. If Reproductive Hormones Are So Important, Why Is There So Much Variation?
2. Coevolution of Biology and Culture: Agriculture and Selection for High Levels of Estrogen
3. You Are What You Eat … as a Fetus
4. The French Paradox: Did Child Welfare Reduce the Risk of Heart Disease?
5. Intergenerational Echoes of Slavery
6. The Price of Reproduction
7. The Ultimate Test of the Costs of Reproduction: Life Span
8. Evolutionary Past and Modern Diet
9. Evolution and Physical Activity
10. Evolutionary Trade-Offs and Culture
11. Fallacies of Philanthropy
12. Fixing Genes versus Fixing Lifestyles
Conclusion: Is Our Physiology Obsolete?
References
Acknowledgments
Index
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