Picornaviruses afflict the animal kingdom with a wide range of maladies, notably the common cold, encephalitis, hepatitis, meningitis, and polio in humans and the economically devastating foot-and-mouth disease in animals. With contributions from leading experts from around the world, this volume examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research. Based on the most recent basic and clinical research findings, The Picornaviruses encapsulates our current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses. In addition, it examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases.

The first eleven chapters explore the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth. The next six chapters illustrate how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness. Together with more drastic recombination events, the book shows how this error-prone RNA replication may have generated the variety of viruses embodied in the different picornavirus genera. The final twelve chapters focus on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.

Synthesizing the latest developments in the study of picornaviruses, the book underscores our growing understanding of the close connections among picornavirus biology, diversity, evolution, and disease. Moreover, it serves as a springboard for developing new approaches to understanding this important family of viruses as well as preventing and treating picornaviral diseases.

Hardcover, 493 pages, full-color insert, illustrations, index.

Vadim I. Agol

Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Kievskoye Shosse 27 km., Moscow Region 142782, Russia

Rubén Agudo

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Raul Andino

Mission Bay Genentech Hall, Microbiology and Immunology, University of California, San Francisco, 600 16th Street, Room S572E, Box 2280, San Francisco, CA 94143-2280

Armando Arias

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

George Belov

Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Room 126, Rockville, MD 20852

Jeffrey M. Bergelson

Division of Infectious Diseases, Abramson 1202, Children’s Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104

Albert Bosch

Department of Microbiology, University of Barcelona, Ave. Diagonal 645, Barcelona 08028, Spain

Mihnea Bostina

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Nora M. Chapman

Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68195-6495

Konstantin Chumakov

Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852

Florence Colbère-Garapin

Biologie des Virus Enteriques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, and INSERM U994 Paris, France

Teresa de los Santos

Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, NY 11944

Armando M. De Palma

Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium

Esteban Domingo

Centro de Biología Molecular Severo Ochoa CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Jonathan D. Dougherty

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030

Ellie Ehrenfeld

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8011

Cristina Escarmís

Centro de Biología Molecular Severo Ochoa CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Zongdi Feng

Division of Infectious Diseases, Department of Medicine, and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295

Cristina Ferrer-Orta

Institut de Biología Molecular de Barcelona, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain

David J. Filman

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Elizabeth E. Fry

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, United Kingdom

Robert S. Fujinami

Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132

Alexander E. Gorbalenya

Department of Medical Microbiology, Leiden University Medical Center, Postzone E4-P, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands

Marvin J. Grubman

Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, NY 11944

Kurt E. Gustin

Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, AZ 85004

Marc B. Hershenson

Department of Pediatrics and Communicable Diseases, C. S. Mott Children’s Hospital, University of Michigan Medical School, Ann Arbor, MI 48109

James M. Hogle

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Tapani Hovi

National Institute for Health and Welfare (THL) P.O. Box 30 FI-00271 Helsinki, Finland

Christopher C. Kemball

Department of Immunology and Microbial Science SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037

Olen Kew

Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333

Andrew M. Q. King

Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, United Kingdom

Karla Kirkegaard

Department of Microbiology and Immunology, Fairchild Science Building D309A, Stanford University School of Medicine, Stanford, CA 94305-5402

Nick J. Knowles

Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, United Kingdom

Satoshi Koike

Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

Chris Lauber

Department of Medical Microbiology, Leiden University Medical Center, Postzone E4-P, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands

Stanley M. Lemon

Division of Infectious Diseases, Department of Medicine, and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295

Hazel Levy

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115

Howard L. Lipton

Department of Microbiology & Immunology, MC790, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612-7344

Richard E. Lloyd

Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030

Encarna Martínez-Salas

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Nicolás Cabrera 1, Cantoblanco, Madrid 28049, Spain

Thomas Michiels

de Duve Institute, Université Catholique de Louvain, 74 avenue Hippocrate, B-1200 Brussels, Belgium

Philip D. Minor

Division of Virology, National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom

Steffen Mueller

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794

David Neubauer

Max F. Perutz Laboratories, Medical University of Vienna, Dr. Bohr-Gasse 9/3, A-1030 Vienna, Austria

Johan Neyts

Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Akio Nomoto

Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan

Ann Palmenberg

Institute for Molecular Virology, University of Wisconsin—Madison, 1525 Linden Drive, Madison, WI 53706

Nogi Park

Department of Basic Medical Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, AZ 85004

Aniko V. Paul

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794

Celia Perales

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, C/Nicolás Cabrera 1, Cantoblanco, Universidad Autónoma de Madrid, Madrid 28049, Spain

Rosa M. Pintó

Department of Microbiology, University of Barcelona, Av. Diagonal 645, Barcelona 08028, Spain

Vincent R. Racaniello

Department of Microbiology & Immunology, Columbia University College of Physicians & Surgeons, Room 1310B, 701 W. 168th Street, New York, NY 10032

Luis L. Rodriguez

Plum Island Animal Disease Center, North Atlantic Area, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 848, Greenport, NY 11944

Raymond P. Roos

Department of Neurology/MC2030, The University of Chicago Medical Center, 5841 S. Maryland Ave., Chicago, IL 60637

David J. Rowlands

Institute for Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom

Janet M. Rozovics

Department of Microbiology and Molecular Genetics, School of Medicine, Medical Sciences I, B214, University of California, Irvine, Irvine, CA 92697-4025

Martin D. Ryan

Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife, Scotland, KY16 9ST, United Kingdom

Bert L. Semler

Department of Microbiology and Molecular Genetics, School of Medicine, Medical Sciences I, B237, University of California, Irvine, CA 92697-4025

Peter Simmonds

Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom

Tim Skern

Max F. Perutz Laboratories, Medical University of Vienna, Dr. Bohr-Gasse 9/3, A-1030 Vienna, Austria

Glyn Stanway

Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex C04 3SQ, United Kingdom

David I. Stuart

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, United Kingdom

Steven Tracy

Department of Pathology and Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68195-6495

Frank van Kuppeveld

Department of Medical Microbiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101 (internal post 268), 6500 HB Nijmegen, The Netherlands

Nuria Verdaguer

Institut de Biología Molecular de Barcelona, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain

Marco Vignuzzi

Viral Populations and Pathogenesis, Institut Pasteur, 75724 Paris cedex 15, France

J. Lindsay Whitton

Department of Immunology and Microbial Science, SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037

Eckard Wimmer

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794