Molecular Biopharmaceutics pdf epub mobi txt 电子书下载 2025

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出版者:Pharmaceutical Press

作者:Steffansen, Bente (EDT)/ Brodin, Birger (EDT)/ Nielson, Carsten U. (EDT)

出品人:

页数:256

译者:

出版时间:2009-12-1

价格:USD 220.00

装帧:Hardcover

isbn号码:9780853697220

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图书标签:

分子生物药剂学
生物制药
药物传递
药物动力学
药物代谢
生物分子
制剂学
生物技术
药物研发
纳米药物

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具体描述

This is an introductory textbook on molecular biopharmaceutics. "Molecular Biopharmaceutics" involves the study of drug absorption, transport and delivery at the molecular level. In particular, increasing knowledge of the molecular structure and function of membrane transporter proteins and the understanding that they play a significant role in drug transport across biological membranes has lead to growing interest in this area from the pharmaceutical industry. This emerging knowledge of membrane transporter proteins has implications for understanding drug disposition and in turn for the development of more effective drug delivery strategies. The text provides an overview of the field of molecular biopharmaceutics, and explains its importance in drug development. It focuses on describing the interplay between the chemistry of drug molecules and membrane transporters, and will guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.

作者简介

目录信息

Part 1 Introduction to Molecular Biopharmaceutics
Part 2 Drug Characterization and Preformulation
1. Pka, Solubility, Liphophilicity and Solid State Characterization of Drug Candidates
2. Stability of Drug Candidates in Aqueous Solutions
3. Kinetics of Acid, Base and Enzyme Catalyzed Hydrolysis
4. Chemical Approaches to Improve Drug Delivery and Formulation of Drug Candidates
5. Preformulation:
Part 3 Drug Delivery Across Biological Membranes
6. Biological Membrane Structures
7. Diffusional Permeation of Drug Candidates
8. Carrier Mediated Transport Kinetics
9. Classification of Human Membrane Transporters
10. Absorptive Transporters
11. Efflux Transporters
12. Preclinical Evaluation of Drug Transport
Part 4 Dosage Form Evaluation
13. In Vitro Drug Dissolution
14. Biopharmaceutical Classification System
15. Biosimulation Studies
Part 5 Conclusions and Future Perspectives
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