Handbook on Immunosenescence pdf epub mobi txt 电子书 下载 2026

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出版者:

作者:Fulop, Tamas (EDT)/ Franceschi, Claudio (EDT)/ Hirokawa, Katsuiki (EDT)

出品人:

页数:1688

译者:

出版时间:2008-11

价格:$ 609.07

装帧:

isbn号码:9781402090622

丛书系列:

图书标签:

• Immunosenescence
• Aging
• Immune System
• Immunology
• Gerontology
• Inflammation
• Vaccination
• Age-related Diseases
• Biomarkers
• Healthspan

The Unfolding Tapestry: A New Synthesis in Developmental Biology This volume offers a comprehensive and deeply nuanced exploration of the intricate processes that govern life’s unfolding from conception through to maturity, situating these events within the broader context of evolutionary pressures and cellular plasticity. Far from being a mere cataloging of developmental milestones, The Unfolding Tapestry presents a cohesive framework for understanding how genetic information is dynamically translated into the complex architecture of a multicellular organism, emphasizing the often-underappreciated interplay between intrinsic molecular signaling and extrinsic environmental cues. The foundational chapters establish a rigorous grounding in the molecular toolkit of development. We delve into the elegant choreography of cell fate determination, moving beyond simple descriptions of signaling pathways to examine the kinetic properties and feedback loops that ensure robustness and precision in decision-making. Specific attention is paid to the role of chromatin remodeling complexes and non-coding RNAs—miRNAs, lncRNAs—not merely as regulators, but as architects that physically shape the accessible genome landscape, thereby pre-determining future developmental trajectories. The discussion is particularly detailed on the mechanisms of epigenetic memory maintenance across successive cell divisions, a crucial element in establishing stable cell identities during organogenesis. A significant portion of the book is dedicated to morphogenesis, the physical construction of form. Here, the synthesis moves fluidly between biophysics and molecular biology. We examine how forces generated at the cellular level—actin-myosin contractility, cell-cell adhesion governed by cadherins and integrins, and hydrostatic pressure—are integrated into macro-scale tissue movements such as gastrulation and neurulation. Detailed case studies, drawn from model organisms spanning from Drosophila to zebrafish, illustrate the principles of self-organization. For instance, the mechanics of convergent extension are analyzed not just as a biological process, but as an emergent property arising from localized changes in cortical tension and cell intercalation, providing quantitative models that bridge the gap between gene expression profiles and observable morphology. The concept of temporal regulation receives novel treatment. Development is inherently time-dependent, and this volume dedicates several sections to dissecting the underlying chronometers. We scrutinize the molecular underpinnings of the developmental clock, exploring the roles of oscillating gene networks (like the segmentation clock) and post-translational modifications, particularly those mediated by ubiquitin ligases and phosphorylation cascades, in timing critical transitions. The transition from embryonic to fetal stages, and subsequently to neonatal and juvenile development, is examined through the lens of hormonal reprogramming, emphasizing how systemic signals—thyroid hormone, growth factors—act as master switches to unlock previously inaccessible developmental programs. A central theme throughout the narrative is plasticity and canalization. How does an organism maintain a robust developmental outcome despite genetic noise or environmental perturbations? The text meticulously maps out the mechanisms underlying canalization, focusing on buffering pathways and redundant regulatory networks. Conversely, we explore the controlled breaking of canalization—developmental plasticity—which allows organisms to adapt phenotype in response to specific, predictable environmental challenges, such as maternal nutritional status or temperature fluctuations. This section includes an in-depth analysis of developmental origins of health and disease (DOHaD), moving beyond simple correlation to propose testable molecular mechanisms linking early life conditions to adult physiological set points. The final sections pivot towards the generative capacity of adult tissues, exploring regeneration and repair. We analyze the differential capacities for regeneration across taxa, contrasting the extensive regenerative abilities of organisms like planaria and axolotls with the more limited, scar-forming repair mechanisms typical of mammalian central nervous system or cardiac tissue. The focus here is on reactivating embryonic signaling pathways. Detailed chapters explore the molecular requirements for successful blastema formation, the necessary breakdown of fibrotic barriers, and the critical role of the niche—the immediate cellular and extracellular matrix environment—in dictating whether progenitor cells proceed toward constructive regeneration or aberrant repair. We examine the cellular dynamics of adult stem cell compartments (hematopoietic, intestinal, neural), paying close attention to how extrinsic signals from the surrounding mesenchyme govern their quiescent states and activation thresholds. Throughout The Unfolding Tapestry, the narrative champions an integrated, systems-level approach. The text relies heavily on quantitative modeling and genomic data analysis to support its mechanistic claims, presenting complex biological scenarios as interlocking networks of causality rather than linear pathways. It is an essential resource for researchers seeking a unified understanding of how an organized living being is constructed, maintained, and repaired across the lifespan, grounded in cutting-edge genomic, proteomic, and biophysical evidence.

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