The story follows a number of Jewish partisans and resistance fighters as they struggle to survive and sabotage the German war machine behind Nazi lines during World War II, starting in eastern Russia and ending in Milan.

The book's chief protagonist, Mendel Nachmanovich Dajcher, worked as a watch repairer before joining the Red Army, where he fought in the artillery. While he is at war, his wife and shtetl are massacred by a German Einsatzgruppe. In the midst of battle, he loses his regiment, becomes disoriented and is overtaken by the front, separated from and unsupported by Soviet forces.

His life thereafter is an odyssey through the "partisanka," the motley partisan movement, which includes Russians, Jews, Lithuanians and Poles. About halfway through the book, Mendel and his companion from the first chapter, Leonid, fall in with a group of Jewish resistance fighters called the gedalistas, after their leader: Gedale.

With them, Mendel traverses Poland and, overtaken by the victorious Soviets, enters defeated Germany. From there, the group aims for Italy, dreaming of making the aliyah to Palestine to take part in the Zionist project of reclaiming a Jewish homeland.

Primo Michele Levi (July 31, 1919 – April 11, 1987) was a Jewish Italian chemist, Holocaust survivor and author of memoirs, short stories, poems, and novels.

He is best known for his work on the Holocaust, and in particular his account of the year he spent as a prisoner in Auschwitz, the infamous death camp in Nazi-occupied Poland. If This Is a Man (published in the United States as Survival in Auschwitz) has been described as one of the most important works of the twentieth century.