Statistical Monitoring of Clinical Trials pdf epub mobi txt 電子書 下載2025
- 臨床試驗
- 統計監測
- 臨床數據管理
- 試驗設計
- 統計學
- 藥物研發
- 生物統計
- 數據分析
- 質量控製
- 方案偏差
具體描述
The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the B-value") - irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials.
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