In recent years the number of new drugs described as enzyme inhibitors has increased significantly. Once an enzyme target is selected or discovered for a particular disease or infection, detailed information must be compiled for the rational design of an inhibitor. Until now, a single handbook containing that crucial background information has not been available. Covering everything you need to know about this complex subject, "Enzymes and Their Inhibition" examines enzyme inhibition in detail, and describes the design and development of such inhibitors. Focusing on the development of enzyme inhibitors as therapeutic drugs, "Enzymes and Their Inhibition" provides an overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss various types of enzyme inhibitors and the principles involved in developing them into effective drugs. "Enzymes and Their Inhibition" describes the problems that can be encountered in translating results from the bench to the market place, and suggests approaches that circumvent these difficulties. This outstanding text for students in pharmacology and medicinal chemistry is also a valuable professional reference.
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