The incidence of diabetes in increasing all over the world and has become a major public health problem. This volume brings together reports from scientists working in the fields of immunology genetics that that report on basic research as well as current approaches to treatment in the clinic. Reports from workshops on autoantibodies and T cells are included, as are chapters covering target autoantigens, innate immunity in type 1 diabetes, fluminant type 1 diabetes, and the role of viral infections in type 1 diabetes. The genetics of LADA and SPIDDM are presented as well as a comparison of their immunoepidemiology and immunopathological features. A section on genetics and the characteristics of susceptible genes concludes the basic research. The clinical topices covered include islet regeneration and the use of stem cells in mediating tolerance for type 1 diabetes prevention. Reports on the progress on islet transplantation conclude the volume. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member