Medicine is an ever-changing science.As new research and clinical exepe-rience broaden our knowledge,changes in treatment and drug therapy are required.The editors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide informaion that is complete and generally in accord with the standards accepted at the time of publication.However,in view of the possibility of human error or changes in medical sciences,neither the editors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete and they disclaim all responsibility for any errors oromissions or for the results obtained from use of such information con-tained in this work.Readers are encouraged to confirm the information contained herein with other sources For example and in particular,read-ers are advised to check the product information sheet included in the package of each drug they plan to be certain that the infor mation contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for adminis tration,This recommendation is of particular importance in connection with new or infrequently used drugs.