This book aims to provide the reader with a simple explanation of some of the fundamental principles of the sciences of pharmacology, therapeutics and toxicology. It sketches the history of drug treatment from traditional therapy with mainly herbal preparations to today's explosion of synthetic drugs. It outlines the roles of the academic research laboratories and the pharmaceutical industry in the development, synthesis, testing and marketing of new drugs. What happens to these drugs when introduced into the body, and how they produce their actions, the good, the bad and the fatal, are the main themes of the first part of this book. The final two chapters address briefly the toxicities produced in our civilized society by the industrial chemicals released into our air, water, soil and food.
This overview aims to help the layman understand the two frequent therapeutic disappointments and unexpected disasters that appear inevitably to accompany the extraordinary progress of medical science over the past hundred years or so. It should enable him to cultivate rational and well-informed opinions on these problems. The widespread problem of pollution in advanced technological societies of our soil, air and water by the chemicals produced intentionally or as waste products by industry can also be better understood from this theoretical background.
The second part is devoted to chemical substances that act on the nervous system, as these include the drugs which are widely abused and can lead to chemical dependence and addiction. Substances acting on the involuntary part of the central nervous system (the autonomic nervous system) which controls blood pressure, cardiac function, respiration, etc., are mentioned, since their modes of action throw light on those chemicals which influence the higher centres, leading to alterations in sensation, mood, behaviour and consciousness. There are chapters on the cause and treatment of mental disorder, the alleviation of anxiety neurosis, insomnia and pain. This leads to a discussion of the nature, cause and treatment of the social problem of drug addiction. These matters are also of great concern to the layman, and there is a need to help him to evaluate intelligently the various panaceas proposed to solve this social disaster.
譯/編/作者簡介
Dr. Michael B. Roberts received his D.Phil. degree in Science from Oxford University in 1946 and M.B.,B.S. and L.M.S.S.A from University of London in 1957. He first taught pharmacology in Aberdeen University Medical School, Scotland, and was the Professor of Pharmacology and Chairman of the Department, University of Hong Kong when he retired in 1980. He has published widely in professional journals and contributed chapters to books.
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这本书的封面设计简直是视觉上的盛宴,那种深邃的墨绿色与烫金的字体形成了一种强烈的对比,透露出一种古典而又神秘的气息。初次翻开,我立刻被作者那如同手术刀般精准的叙事方式所吸引。他似乎能洞察人性的每一个细微角落,将那些我们通常选择视而不见的阴影赤裸裸地展示出来。文字的密度极高,需要我放慢呼吸,细细咀嚼每一个词语的重量。尤其是在描述角色内心的挣扎时,那种压抑感几乎要穿透纸页,让人感到胸口发闷。我记得有一个段落,主角面对一个道德困境,作者用了近乎诗歌的排比句式来描绘他脑海中天人交战的景象,那不是简单的善恶二元对立,而是一片广袤的灰色地带,充满了复杂的情感纠葛和无可奈何的宿命感。读到那里,我不得不合上书本,走到窗边,让清凉的空气灌进肺里,试图消化那股扑面而来的沉重。这本书的结构也十分巧妙,它并非线性叙事,而是像一个精密的钟表,各个时间线看似独立,却在关键时刻以一种令人拍案叫绝的方式交织在一起,让人忍不住惊叹于作者对全局的掌控力。这绝不是一本可以轻松消遣的作品,它要求读者付出全部的专注和心力,但回报是极其丰厚的——对自身和世界的理解,都将因此而加深一个维度。
评分这本书的语言风格变化多端,简直像一个切换自如的变色龙。有时候,它的文风会突然变得极其口语化和粗粝,充满了街头巷尾的烟火气和粗俗的生命力,仿佛能闻到潮湿的柏油路面和劣质香烟的味道。但下一秒,它又会陡然转向一种高度抽象和哲学化的探讨,用近乎学术论文的严谨来解构某种人类的原始冲动。这种强烈的反差,初读时可能会让人感到突兀,但很快就会适应并沉浸其中。我猜想,作者一定阅读了大量的跨学科资料,才能将心理学、社会学、甚至一些晦涩的古典哲学概念,如此自然地融入到故事的肌理之中。特别是关于“责任的转嫁”那几章,作者引用了一些古老的法律条文来佐证角色的行为逻辑,那种既古代又现代的交错感,让人不禁深思,人类的道德困境是否从未真正改变过,只是外衣换了新的样式。这使得阅读体验非常立体,仿佛不只是在看一个故事,而是在参与一场多层次的辩论。
评分我必须承认,读这本书需要极大的耐心和一定的阅读储备。这不是那种可以边听音乐边轻松翻阅的书籍。作者对细节的痴迷近乎偏执,他会花上大篇幅去描述一个房间的陈设,或是一件物品的历史,这些看似“跑题”的描写,实则都是为最终的主题服务的,它们是构建角色心理世界不可或缺的砖石。这种写作手法对我来说是一种挑战,有几次我差点因为过于冗长而感到不耐烦,但坚持读下去后,你会发现,正是这些看似无用的铺垫,才使得最后的高潮爆发得如此合乎情理,具有无可辩驳的力量。它让你明白,伟大的悲剧往往不是由单一的灾难事件造成的,而是由无数个微小、被忽视的累积所铸就的。这本书教会了我一种新的阅读方式:慢下来,去欣赏文字背后的呼吸和节奏,去感受每一个场景是如何被精心构建起来的。它更像是一部文学雕塑,需要从各个角度去审视其纹理和光影。
评分这本书最令我震撼的,是它对“受害者心态”的深刻挖掘。许多作品都描绘了受害者,但往往停留在同情和控诉的层面。而这部作品则走得更远,它毫不留情地撕开了受害者如何在无意识中成为了“施害者”的同谋,如何利用自己的痛苦去操纵环境和他人,以此来维持一种扭曲的平衡。书中有一个角色,她的每一句“求助”都精准地击中了身边人的愧疚感和责任心,最终将所有人都拖入了共同的泥潭。这种对人性的阴暗面的坦诚,让我感到既痛苦又无比清醒。它迫使你审视自己,是否也曾用“我太难了”来为自己的不作为开脱。这不是一本让人读完后感觉舒服的书,它更像是一次深层的心灵手术,刀口深,过程痛苦,但清理掉了许多长期潜伏的毒瘤。读完最后一页,我久久没有合上,感觉自己像刚从一场漫长的、关于存在的审判中走出来,虽然疲惫不堪,但灵魂似乎被重新校准了一次,对世界的理解变得更加复杂,也更加接近真实。
评分说实话,我一开始对这种题材并不抱太大期望,总觉得探讨“毒性”的主题很容易落入俗套,无非就是渲染一些夸张的负面情绪,制造廉价的冲击感。然而,这部作品完全颠覆了我的固有印象。它没有急于下结论,而是像一个耐心的博物学家,细致入微地观察和记录着人际关系中的“毒素”是如何缓慢渗透、潜移默化地改变一个人的。我尤其欣赏作者对“环境”的刻画,那种渗透到日常对话、家具摆设、甚至是光线角度里的微妙暗示,让人感到不寒而栗。比如,书中对一个家庭聚会的描写,表面上是其乐融融,但细读之下,每一个看似无伤大雅的玩笑背后都藏着一把淬了毒的匕首,直指对方最脆弱的痛处。这种高明的“不动声色”,比直接的冲突更让人感到恐惧,因为它揭示了我们赖以生存的社会互动机制中,有多少是建立在脆弱的平衡和潜在的恶意之上的。阅读过程中,我经常会停下来,对照自己过往的一些经历,然后猛地意识到,原来那些我以为是“小摩擦”的事情,可能早已埋下了更深的隐患。这本书像一面魔镜,照见的不仅是书中的角色,更是我们自己。
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